Kudziyesa nokha ndi mayeso a antigen ngati njira yochepetsera SARS-CoV-2

Mu mliri wa COVID-19, kupereka chithandizo chokwanira chaumoyo kwa odwala ndikofunikira kuti kufa kuchepe.Zachipatala, makamaka ogwira ntchito zachipatala zadzidzidzi, omwe akuyimira mzere woyamba wankhondo yolimbana ndi COVID-19 [1].Ndi munthawi yachipatala kuti wodwala aliyense alandire chithandizo ngati wodwala yemwe angathe kupatsirana, ndipo zidawonetsa makamaka zachipatala zomwe zikugwira ntchito kutsogolo pachiwopsezo cha matenda a SARS-CoV-2 [2].Mukuwunika mwadongosolo, Bandyopadhyay et al.fufuzani zambiri za 152,888 HCWs matenda amasonyeza imfa pa 0.9% mlingo [3].Komabe, amawerengeranso imfa -
37.2 imfa pa matenda 100 aliwonse a HCWs pazaka 70.Rivett et al.3% yoyesedwa mu gulu loyang'ana asymptomatic ya HCW anali SARS-CoV-2 positive [4].Kuyezetsa kolondola kumathandiza kudziwa anthu omwe angafunike chithandizo, kapena omwe akufunika kudzipatula kuti apewe kufalikira kwa matenda.Mogwirizana ndi zomwe tafotokozazi, kuyezetsa zinthu zamwadzidzidzi zomwe zili ndi zizindikiro zochepa kapena zopanda zizindikiro ndizofunika kwambiri poteteza odwala
ndi onse ogwira ntchito zachipatala.

NEWS

Chithunzi 1. Momwe mungawerengere zotsatira za mayeso.
Kupezeka kowonjezereka kwa mayeso a antigen kumapangitsa kuti azigwiritsa ntchito kuchipatala, kuchipatala komanso kunyumba.Kutsimikizika kwa mayeso a immunological omwe amapeza ma antigen a AG amatsimikizira kachilombo ka SARS-CoV-2 [5].Pakadali pano, kuyezetsa kwa antigen kwadziwika kuti ndikofanana ndi kuyesa kwa majini kochitidwa ndi RT-qPCR.Mayesero ena amafunikira chitsanzo cha m'mphuno chomwe chingasonkhanitsidwe pogwiritsa ntchito swab ya m'mphuno yam'mphuno kapena mphuno yapakati pa turbinate swab, ena amafuna chitsanzo cha malovu.Chotsatira mukatolera zamoyo ndikusakaniza ndi madzimadzi otchingira.Kenako, mutathira madontho angapo (malingana ndi wopanga mayeso) wa zitsanzo zomwe zayesedwa, conjugate ya antibody ya golide imakhala ndi hy-drated ndipo antigen ya COVID-19, ngati ilipo mu zitsanzo, ilumikizana ndi golide-conjugated ma antibodies.Antigen-antibody-gold com-plex idzasamukira ku zenera loyesera mpaka ku Zone Yoyesera, kumene idzagwidwa ndi ma antibodies osasunthika, ndikupanga mzere wowoneka wa pinki (Assay Band) wosonyeza zotsatira zabwino.Ubwino wa kuyezetsa kwa antigen mwachangu, kutengera lateral flow immunochromatographic as-says (LFIA), ndikuzindikirika kwakanthawi kochepa, pomwe zovuta zawo ndizochepa kumva kuposa RT-qPCR komanso kuthekera kopeza zotsatira zoyipa mwa munthu yemwe ali ndi kachilombo. ndi SARS-CoV-2.Kafukufuku yemwe adasindikizidwa koyambirira kwa mliri wa COVID-19 adawonetsa kuti kukhudzidwa kwa m'badwo woyamba wamayeso othamanga omwe adazindikira ma antigen a SARS-CoV-2 omwe adayesedwa adachokera pa 34% mpaka 80% [6].Chifukwa cha kuthekera kopeza zotsatira mumphindi zochepa kapena zingapo, mtundu wachiwiri wa mayeso a antigen ndi chida chachangu komanso choyenera chodziwira, ndipo masiku ano mphamvu yake ndiyokwera kwambiri ≥90% ndi kutsimikizika ≥97% .Chitsanzo cha kuyesa koteroko ndi kuyesa kofulumira kwa antigen COVID-19 (SG Diagnostics, Singapore), malangizo otanthauzira zotsatira adaperekedwa mumkuyu 1.

Mayeso a antigen adadziwikanso pakuwunika odwala omwe ali okonzeka kale kuchipatala.Chitsanzo cha kugwiritsa ntchito mayeso a antigen a COVID-19 pachipatala cha prehospital akhoza kukhala Emergency Medical Services ku Warsaw (Poland), pomwe wodwala aliyense yemwe akuganiziridwa kuti ali ndi COVID-19 kapena kukhudzana ndi wodwalayo amatha kudwala msanga mayeso, chifukwa omwe azachipatala amadziwa ngati akuyenera kupita kuchipatala choperekedwa kwa odwala COVID-19 kapena chipatala chabwinobwino [7].Kuyesa kwachangu kwa antigen kuyenera kugwiritsidwa ntchito pozindikira matenda a mphuno ya SARS-CoV-2 makamaka mwa odwala omwe ali ndi zizindikiro m'masiku oyamba 5-7 chizindikirocho chitangoyamba kumene.Anthu omwe ali ndi zizindikiro zoyeserera za SARS-CoV-2 antigen ayenera kuthandizidwa ngati ali ndi kachilombo.Zotsatira zoyipa zakuyezetsaku zimafunikira kutsimikiziridwa ngati chithunzi chachipatala kapena malo owopsa a miliri akuwonetsa kuti ali ndi kachilombo ka COVID-19, chifukwa zotsatira zoyipa za mayeso a antigen sizimapatula kachilomboka.

Mwachidule, kuyang'ana zinthu zachipatala mwadzidzidzi ndi odwala EMS omwe ali ndi zizindikiro zochepa kapena opanda zizindikiro ndi njira yomwe idzakhala yofunikira kwambiri poteteza odwala ndi onse ogwira ntchito zachipatala.


Nthawi yotumiza: Nov-27-2021